Publications and Patents (us) in reverse chronological order

[first-author (*) and corresponding author (#) papers from the lab. Lab members are shown in bold and Publications #1-#25 are papers by Yea Eun Kang published elsewhere as a residency or fellowship.]

2024

77.  Lee, S.E.*, Park, S.*., Yi,S. , Choi, N.R., ..., Ju, Y.S., Kim, S.K., Koo, B.S.#, Kang. Y.E.#. Unraveling the role of the mitochondrial one-carbon pathway in undifferentiated thyroid cancer by multi-omics analyses Natrue Communications.  2024. PMID: 38331894

2023  

76.  Lakhani , A., Kang, D.H., Kang, Y.E.#, Park. J# Toward Systems-Level Metabolic Analysis in Endocrine Disorders and Cancer. Endocrinology and Metabolism.  2023. PMID:37989266

75.  Lee, S.E., Choi, N.R., ... Koo, B.S.#, Kang. Y.E.#.The role of De novo serine biosynthesis from glucose in papillary thyroid cancer  International Journal of Thyroidology 2023. 16.2 (2023): 175-183. 

74. Sim, BC*, Kang, Y. E*., You, S.K.*, Lee, S.E. , ..., Lee, J.E. and Yi, H-S. Hepatic T-cell senescence and exhaustion are implicated in the progression of fatty liver disease in patients with type 2 diabetes and mouse model with nonalcoholic steatohepatitis. Cell death and disesase. 2023.  PMID: 37735474

73.  Kim, M#., Kang, Y. E#., Park, Y. J., Koo, B. S., Ku, E. J., Choi, J. Y., ... & Kim, B. H. Potential impact of obesity on the aggressiveness of low-to intermediate-risk papillary thyroid carcinoma: results from a MASTER cohort study. Endocrine. 2023.  https://doi.org/10.1007/s12020-023-03416-5 

72. Song, M. K., Kim, J. E., Kim, J. T., Kang, Y. E., Han, S. J., Kim, S. H., ... & Lee, J. H. GDF10 is related to obesity as an adipokine derived from subcutaneous adipose tissue. Frontiers in Endocrinology, 14, 1159515. 2023.

71. Kang YM, Koo BS, Yi H,..., Kang YE#. Association between DIO2 Thr92Ala polymorphism and hypertension in patients with hypothyroidism: Korean Genome and Epidemiology Study. The Korean Journal of Internal Medicine. 2023. PMID: 36646987

​70. Hong G, Sun P, Chung C,..., Kang YE#, Kang DH#. Plasma GDF15 levels associated with circulating immune cells predict the efficacy of PD-1/PD-L1 inhibitor treatment and prognosis in patients with advanced non- small cell lung cancer. Journal of Cancer Research and Clinical Oncology.  2023. PMID:36472770

69. Kang DH, Song M, Ju SH, Lee SI, Kang YE#. Propylthiouracil-Induced Antineutrophil Cytoplasmic Antibody-Positive Vasculitis and Agranulocytosis: A Rare Case with Life-Threatening Multiple Systemic Manifestations.  Endocrinology and Metabolism. 2023. PMID: 36914241

68. Won H, Jeon E, Heo Da, ...., Kang YE, Yi H, Lee JH, Koo BS.  ASO Author Reflections:  Active Surveillance may be Possible in Patients with T1b Papillary Thyroid Carcinoma Over 55 Years of Age Without High-Risk Features on Preoperative Examinations. Annals of Surgical Oncology. 2023. PMID: 36629990

67. Kim HJ, Nguyen Q, ..., Kang YE, Kim J, Kim YI, Koo BS. Mitochondrial ribosomal protein L14 promotes cell growth and invasion through modulating ROS in thyroid cancer. Clinical and Experimental Otorhinolaryngology. 2023. PMID: 36822197

66.  Won H, Jeon E, Heo Da, ...., Kang YE, Yi H, Lee JH, Koo BS. Age-dependent Clinicopathological Characteristics of Patients with T1b Papillary Thyroid Carcinoma: Implications for the Possibility of Active Surveillance. Clinical and Experimental Otorhinolaryngology. 2023. PMID:36581723

65. Kim S, Ha Y, Kim JM, Kim KH, Kang YE#. A rare adrenocorticotropic hormone-producing nasal neuroendocrine tumor with multiple metastasis. The Korean Journal of Internal Medicine. 2023. PMID: 36050276

64. Hong Y, Kim HJ, Park S, Yi S, Lim MA, Lee SE,..., Koo BS#, Park W#, Kang YE#. Single cell analysis of human thyroid reveals the transcriptional signatures of aging. Endocrinology. 2023. PMID: 36791033

63. Kang YE*, Kim S, Lee SE, Yi S, Lim MA. Composition for preventing or treating keloid. US Patent App. 17/818,378 

2022

62. Hong HJ, Joung KH, Kim YK, Choi MJ, Kang SG, Kim JT, Kang YE,..., Kim H, Park K, Kim HJ, Shong M. Mitoribosome insufficiency in β cells is associated with type 2 diabetes-like islet failure. Experimental & Molecular Medicine. 2022. PMID: 35804190

61. Jin Y, Jung S, Lim MA, ..., Kang YE, Chang JW, Won H, Koo BS. SHMT2 Induces Stemness and Progression of Head and Neck Cancer. International Journal of Molecular Sciences. 2022. PMID: 36077112

60. Lee S, Lee M, Jo S, Yoo I, Sarankhuu B, Kim H, Kang YE, ..., Park M, Song JH. Effects and Mechanism of Particulate Matter on Tendon Healing Based on Integrated Analysis of DNA Methylation and RNA Sequencing Data in a Rat Model.  International Journal of Molecular Sciences. 2022. PMID: 35897746

59. Setoyama D, Lee HY, Moo JS,..., Kang YE, Lee JH, Shong M, Yi HS.  Immunometabolic signatures predict recovery from thyrotoxic myopathy in patients with Graves' disease. Journal of cachexia, sarcopenia and muscle. 2022. PMID: 34970859

58. Won H, Jeon E, Chang JW, Kang YE,...,Chung, K, Kim H, Koo BS. Is maintaining thyroid-stimulating hormone effective in patients undergoing thyroid lobectomy for low-risk differentiated thyroid cancer? A systematic review and meta-analysis. Cancers. 2022. PMID:  35326621.

57. Kim JT, Lim MA, Lee SE, Kim HJ,...,Shin HS, Shong M, Koo BS#, Kang YE#. Adrenomedullin2 stimulates progression of thyroid cancer in mice and humans under nutrient excess conditions. Journal of Pathology. 2022. PMID: 36098211. 

56. Yi S*, Kim HJ, Koo BS, Lee SE, Choi J, Kang YE#. Efficient Dissociation Protocol for Generation of Single Cell Suspension from Human Thyroid Tissue for Single Cell RNA Sequencing. Endocrinology and Metabolism. 2022. PMID: 36065649. 

55. Kang YE*, Yi HS, Yeo MK,..., Lee SE, Kim JM, Joung KH, Kim HJ. Increased Pro-Inflammatory T Cells, Senescent T Cells, and Immune-Check Point Molecules in the Placentas of Patients With Gestational Diabetes Mellitus. Journal of Korean Medical Science. 2022. PMID: 36513052.

54. Lee MJ, Zhu J, An JH, Lee SE, Kim TY, Oh E, Kang YE#, Chung W#, Heo JY#.  A transcriptomic analysis of cerebral microvessels reveals the involvement of Notch1 signaling in endothelial mitochondrial-dysfunction-dependent BBB disruption. Fluids and Barriers of the CNS. 2022. PMID: 36028880.

53. Jeon M*, Kang YE*, Moon JH,...,Cho SW, Kim WB. Protocol for a Korean Multicenter Prospective Cohort Study of Active Surveillance or Surgery (KoMPASS) in Papillary Thyroid Microcarcinoma.  Endocrinology and Metabolism. 2022. PMID: 33752303.

52. Ju S, Lee SE, Kang YE, Shong M. Development of Metabolic Synthetic Lethality and Its Implications for Thyroid Cancer. Endocrinology and Metabolism. 2022. PMID: 35255601

51. Kang YE*, Joung KH, Kim JM, Lee JH, Kim HJ, Ku BJ.  Serum CD14 concentration is associated with obesity and insulin resistance in non-diabetic individuals. Journal of International Medical Research.  2022. PMID:36224747.

50. Park S*. Kang YE*, Kim J, Park J,..., Koo BS, Kim SY. Transcriptomic analysis of papillary thyroid cancer: A focus on immune-subtyping, oncogenic fusion, and recurrence. Clinical and Experimental Otorhinolaryngology. 2022. PMID: 35255661. 

49. Piao Y, Lee JH, Ju SH, Yi HS,...,Koo BS#, Kang YE#. Completion thyroidectomy may not be required for papillary thyroid carcinoma with multifocality, lymphovascular invasion, extrathyroidal extension to the strap muscles, or five or more central lymph node micrometastasis. Oral Oncology. 2022. PMID: 36108524.

2021

48. Oh C, Won HR, Kang WS, Kim DW, Jung SN, Lim MA, ..., Kang YE,.., Chang JW, Koo BS. Head and neck cancer cell death due to mitochondrial damage induced by reactive oxygen species from nonthermal plasma-activated media: Based on transcriptomic analysis. Oxidative Medicine and Cellular Longevity. 2022. PMID: 34306318.

47. Kang SG, Choi MJ, Jung S, Chung HK, Chang JY, Kim JT, Kang YE,..., Johan Auwers, Yi HS, Shong M. Differential roles of GDF15 and FGF21 in systemic metabolic adaptation to the mitochondrial integrated stress response.  iScience. PMID: 33718833.

46. Lee JH, Jung S, Lee SE,...,Kang YE, Kang SG, Yi HS, Ko YB, Lee KH, Kim HJ. Expression of LONP1 is high in visceral adipose tissue in obesity, and is associated with glucose and lipid metabolism.  Endocrinology and Metabolism. 2021. PMID: 34154043. 

45. Jin M, Kim ES, Kim BH, Kim HK, Kang YE, Jeon MJ, Kim TY, Kang H, Kim WB, Shong YK. Clinicopathological Characteristics and Disease-Free Survival in Patients with Hürthle Cell Carcinoma: A Multicenter Cohort Study in South Korea. Endocrinology and Metabolism. 2021. PMID: 34731935. 

44. Kim S*, Lee SE*, Yi S, ..., Kang YE#,Oh SH#. Tauroursodeoxycholic Acid Decreases Keloid Formation by Reducing Endoplasmic Reticulum Stress as Implicated in the Pathogenesis of Keloid. International Journal of Molecular Sciences. 2021. PMID: 34639105.

43. Jung SN, Oh C, Chang JW, ..., Lee SE, Kang YE#, Koo BS#. EGR1/GADD45α activation by ROS of non-thermal plasma mediates cell death in thyroid carcinoma. Cancers.  2021. PMID: 33477921. 

42. Lee EK*, Kang YE*, Park YJ, ..., Go S, Kang YM, Master study group. A multicenter, randomized, controlled trial for assessing the usefulness of suppressing thyroid stimulating hormone target levels after thyroid lobectomy in low to intermediate risk thyroid cancer patients (MASTER): a study protocol.  Endocrinology and Metabolism. 2021. PMID: 34034365.

41. Kang S, Lee SE. Choi MJ,..., Kang YE, Lee JH, Yi HS, Shong M. Th2 cytokines increase the expression of fibroblast growth factor 21 in the liver. Cells. 2021. PMID: 34073755.

40. Kang YE*, Kim JM, Lim MA, Lee SE, Yi S, ..., Koo BS, Shong M. Growth differentiation factor 15 is a cancer cell-induced mitokine that primes thyroid cancer cells for invasiveness. Thyroid. 2021. PMID: 33256569.

39. Jin Y, Jung SN, Lim MA, ..., Kang YE, Chang JW, Won H, Koo BS. Transcriptional regulation of GDF15 by EGR1 promotes head and neck cancer progression through a positive feedback loop. International Journal of Molecular Sciences. 2021. PMID:34681812.

38. Lee JC, Song B, Kang YM, Kim Y, Kang YE, Lee JH, Shong M, Yi HS. Effect of thyroid-stimulating hormone suppression on muscle function after total thyroidectomy in patients with thyroid cancer. Frontiers in Endocrinology. 2021. PMID: 34858341.

2020

37.  Kang YE*, Shong M. Adm2 gene marker for diagnosis or prognosis prediction of thyroid cancer and uses thereof. US patent. 

36. Won H, Jung SN, Yeo MK, Yi S,...,Kang YE, Chang JW, Rha KS, Koo BS. Effect of Urban Particulate Matter on Vocal Fold Fibrosis through the MAPK/NF-κB Signaling Pathway. International Journal of Molecular Sciences. 2020. PMID: 32927894. 

35. Kang YE*, Kang YM, Park B, Shong M, Yi HS. Type 2 deiodinase Thr92Ala polymorphism is associated with a reduction in bone mineral density: A community‐based korean genome and epidemiology study. Clinical endocrinology. 2020. PMID: 32324283. 

34. Kang YE*, Hwang B, Lee JH, Shong M, Yi HS, Koo BS, Lee DJ. The Significance of Transcriptomic Signatures in the Multifocal Papillary Thyroid Carcinoma: Two mRNA Expression Patterns with Distinctive Clinical Behavior from The Cancer Genome Atlas (TCGA) Database. Internationa Journal of Thyroidology. 2020.

33. Jung S*,Kang YE*, Lee GH, Liu L, Oh C,.., Won HR, Koo BS. Brn3a/Pou4f1 functions as a tumor suppressor by targeting c-MET/STAT3 signaling in thyroid cancer. The Journal of Clinical Endocrinology & Metabolism. 2020. PMID: 32474599. 

32. Lee K, Lee S, Kim W, Lee J,..., Kang YE, Shong M, Lee HJ, Kim KS. Dsg2-mediated c-Met activation in anaplastic thyroid cancer motility and invasion. Endocrine-Related Cancer. 2020. PMID: 33022637.  

31. Lee G*, Kang YE*; Oh C,..., Chang JW, Koo BS.  Neuropilin-2 promotes growth and progression of papillary thyroid cancer cells. Auris Nasus Larynx. 2020. PMID: 32381353.

2019

30. Kang YE*, Kim JM, Yi HS, Joung KH, Lee JH, Kim HJ, Ku BJ. Serum R-Spondin 1 is a new surrogate marker for obesity and insulin resistance. Diabetes & Metabolism Journal. 2019. PMID: 30398036.

29.  Kang YE*, Kim HJ, Shong M. Regulation of systemic glucose homeostasis by T helper type 2 cytokines. Diabetes & Metabolism Journal. 2019. PMID: 31694077.

28. Yi HS. Kim SY,..., Kang YE, Joung KH, Lee JH, Kim HJ, Ku BJ. T-cell senescence contributes to abnormal glucose homeostasis in humans and mice. Cell death & disease. 2019. PMID: 30867412.

27. Kang YE*, Kim JT*, Lim MA, Oh C, Liu L, ..., Koo BS, Shong M. Association between circulating fibroblast growth factor 21 and aggressiveness in thyroid cancer. Cancers. 2019. PMID: 31408968.

2018

26. Won HR, Chang JW, Kang YE, Kang JY, Koo BS. Optimal extent of lateral neck dissection for well-differentiated thyroid carcinoma with metastatic lateral neck lymph nodes: a systematic review and meta-analysis. Oral Oncology.  2018. PMID: 30527226.

25. Lee JH, Kim JM, Choi MJ, ..., Kang YE, Joung KH, Yi SH, Kim KS, Ku BJ, Koo BS, Shong M. Clinical implications of UCP1 mRNA expression in human cervical adipose tissue under physiological conditions. Obesity. 2018. PMID: 29698580.

24. Lee JH, Kang YE,Kim JM, ..., Kim HJ, Ku BJ. Serum Meteorin-like protein levels decreased in patients newly diagnosed with type 2 diabetes. Diabetes research and clinical practice. 2018. PMID: 29097285.

23. Kang YE*, Jeong J, Kim K, Ki CS, Kim HJ. Malignant intercostal psammomatous melanotic schwannoma in a patient with Carney complex. The Korean Journal of Internal Medicine. 2018. PMID: 29132201.

22. Kim SY, Lee Y, Kang YE, ...,Shong M, Yi HS. Genetic analysis of CLCN7 in an old female patient with type II autosomal dominant osteopetrosis. Endocrinology and Metabolism. 2018. PMID: 30229577.

21. Kang YE*, Shong M, Kim JM, Koo BS.  Prognostic Significance of Sirtuins Expression in Papillary Thyroid Carcinoma. International Journal of Thyroidology. 2018. 

2017

20. Kang YE*, Kim JM, ..., Kim HW, Kim JT, Lee K, Shong M. Upregulation of RSPO2-GPR48/LGR4 signaling in papillary thyroid carcinoma contributes to tumor progression. Oncotarget. 2017. PMID: 29383135. 

19. Lee J, Yi S, Chang JY, Kang YE,..., Yi HS, Shong M. Regeneration of thyroid follicles from primordial cells in a murine thyroidectomized model. Laboratory investigation. 2017. PMID:  28112758.

18. Kang YE*, Choung S, Lee JH, Kim HJ, Ku BJ.  The role of circulating Slit2, the one of the newly batokines, in human diabetes mellitus. Endocrinology and Metabolism. 2017. PMID: 28956369.

17. Kang YE*, Kim KS,..., Yi S, Jung MG, Kim JM, Koo BS. High expression of angiopoietin-1 is associated with lymph node metastasis and invasiveness of papillary thyroid carcinoma. World Journal of Surgery. 2017. PMID:  28717903.

16. Lee Y, Yi HS, Kim HR, Joung KH, Kang YE, Shong M. The eosinophil count tends to be negatively associated with levels of serum glucose in patients with adrenal cushing syndrome. Endocrinology and Metabolism. 2017. PMID: 28956365. 

2016

15. Lee JH*, Kang YE*, Hwang JH, ..., Chung HK, Kim KS. Engineered FGF21 variant, LY2405319, can protect nonalcoholic fatty liver disease through enhancing hepatic mitochondrial function. American Journal of Translational Research. PMID: 27904677.

14. Kang YE*, Kim JM, ..., Kim HJ, Ku BJ. Comparison of serum Neuregulin 4 (Nrg4) levels in adults with newly diagnosed type 2 diabetes mellitus and controls without diabetes. Diabetes research and clinical practice. 2016. PMID: 27329015.

13. Lee J, Yi S, Kang YE, .., Kim KS, Shong M. Morphological and functional changes in the thyroid follicles of the aged murine and humans. Journal of pathology and translational medicine. 2016. PMID: 27737529.

12. Lee J, Yi Shinae, Kang YE,..., Kim J, Porcelli A, Shong M. Defective ciliogenesis in thyroid hürthle cell tumors is associated with increased autophagy. Oncotarget. 2016. PMID: 27816963.

11. Kang  YE*,  Kim JM, ..., Kim HJ, Ku BJ. Treatment with gefitinib, an epidermal growth factor receptor inhibitor, decreases serum cholesterol in patients with lung cancer. The Korean Journal of Obesity. 2016. 

10. Kang YE*, Kim, JM, Joung KH,..., Lee KH, Kim HJ. The roles of adipokines, proinflammatory cytokines, and adipose tissue macrophages in obesity-associated insulin resistance in modest obesity and early metabolic dysfunction. Plos One. 2016. PMID: 27101398.

9. Shin MY, Kim JM, Kang YE,..., Ku BJ, Shong M. Association between growth differentiation factor 15 (GDF15) and cardiovascular risk in patients with newly diagnosed type 2 diabetes mellitus. Journal of Korean Medical Science. 2016. PMID: 27510384

2015

8. Lee J, Chang JY, Kang YE,..., Kim KS, Shong M. Mitochondrial energy metabolism and thyroid cancers. Endocrinology and Metabolism. 2015. PMID: 26194071.   

7. Kong SE*, Kang YE*, ..., Kim HJ, Ku BJ. Plasma adiponectin levels in elderly patients with prediabetes. Endocrinology and Metabolism. 2015. PMID:  26248857  

6. Shin, MY, Kang YE, ..., Kim KS. A case of low bone mineral density with vitamin d deficiency due to prolonged lactation and severe malnutrition. Journal of bone metabolism. 2015. PMID: 25774364  

2012~2014

5. Kang YE*, Hong JH,..., Ku BJ, Kim KS. A novel PHEX gene mutation in a patient with sporadic hypophosphatemic rickets. Endocrinology and Metabolism. 2014. PMID:  25031893.

4. Hong JH, Jang HW, Kang YE,..., Park KR, Ku BJ. Urinary chiro-and myo-inositol levels as a biological marker for type 2 diabetes mellitus. Disease markers. 2012. PMID:  22960342.  

3. Kim HJ, Lee IS, Kim JM, Jung H, Kang YE,..., Ku BJ. Pinitol does not affect glucose levels, insulin resistance and the adipocytokine in prediabetic individuals-a preliminary study. Current Topics in Nutraceutical Research. 2012. 

2. Kim TK, Kang YE, Kim JM,..., Kim YK, Ku BJ. Effects of Diabetic Camp in Type 2 Diabetic Patients. The Korean Journal of Medicine. 2012. 

1. Kang YE, Kim TK, Jung, H, Kim, HJ, Son KM, Ku, BJ. Streptococcus pneumoniae infection after acupuncture and moxibustion in a patient with type 2 diabetes mellitus. Acta endocrinologica. 2012.